The Zambian Super League giants will travel to Sudan for the first leg on Friday, and have named six new signings in their matchday squad.
The new inclusions are striker Luka Lungu, who returned to Dynamos in January after spending three years with Democratic Republic of Congo side Don Bosco, as well as defenders Christopher Munthali, Derrick Mwansa and White Mwanambaba, and midfielders Kelvin Mubanga and Larry Bwalya.
Dynamos will now jet off to Sudan from Kenya, where they have been undergoing a week-long training camp, which included friendly matches against Kenyan Premier League champions Gor Mahia and last year's runners-up Sofapaka.
The return fixture will see Power host Al Khartoum SC in Kitwe on February 28.
Power Dynamos CAF Confederations Cup squad:
Goalkeepers: Joshua Titima, Joel Kanyeba, Berky Bizangi;
Defenders: Govender Simwala, Billy mutale, Christopher Munthali, Lawrence Chungu, White Mwanambaba, Derrick Mwansa;
Midfielders: Larry Bwalya, Kennedy Mudenda, Kelvin Mubanga, Thomas Nyirenda, Emmanuel Chimpinde, Richard Kasonde, Julius Situmbeko;
Strikers: Alex Ngonga, Jimmy Ndhlovu, Luka Lungu, Ignatius Lwipa.