Farouk Miya, who plays for the Vipers club in Kampala, delivered the stinging blow nine minutes from time in the southern city of Uyo with a deflected close-range shot that looped into the net. Enyeama is the second Nigerian after retired former Everton defender Joseph Yobo to make 100 appearances for the Super Eagles. And he is the fourth African shot-stopper after Egyptians Essam El-Hadary, Nader El-Sayed and Ahmed Shobair to become an international centurion.
Enyeama plays for French Ligue 1 outfit Lille and the 32-year-old is widely regarded as the best current African goalkeeper. Nigeria are rebuilding after failing to qualify for the 2015 CAF Africa Cup of Nations and rarely threatened to score against the well-organised Ugandans also captained by their goalkeeper, Denis Onyango.
Thulani Hlatshwayo, skippering Bafana Bafana (The Boys) for the first time, and debutant Thabo Mnyamane scored early second-goals. Felix Badenhorst halved the deficit only for Mandla Masango to put the outcome beyond doubt with a third South African goal.
Gabon pipped Mali 4-3 in a thriller at Stade Pierre Basson in the northern French city of Beauvais with Bruno Ecuele Manga snatching the last-minute match-winner. Borussia Dortmund goal-poacher Pierre-Emerick Aubameyang, runner-up to Côte d'Ivoire and Manchester City midfielder Yaya Toure in the 2014 CAF Footballer of the Year poll, scored twice for Gabon. French coach Alain Giresse was in charge of Mali for the first time since rejoining the Eagles after a spell with Senegal.
Porto striker Vincent Aboubakar poked a cut-back into the net on 36 minutes to earn Cameroon a 1-0 victory in Indonesia. Cameroon 1990 FIFA World Cup™ legend Roger Milla labelled the fixture "humiliating", saying the four-time African champions should be playing better quality opposition.
Burundi equalised twice to draw 2-2 in Mauritius and prevent French coach Didier Six celebrating his debut in charge of the Indian Ocean islanders with a victory. Andy Sophie put the Mauritians ahead on ten minutes and Burundi levelled through a penalty before Bruno Ravina restored the lead midway through the opening half.
A 2-0 home win for Botswana over fellow southern Africa nation Lesotho completed a six-friendly schedule designed to prepare teams for the June kick-off of the 2017 CAF Cup of Nations qualifiers.