Mazembe won 2-1 at USM Alger of Algeria last Saturday in the first leg of the final with a starting line-up consisting of three Malians plus two stars each from DR Congo, Ghana, Tanzania and Zambia.
"The major focus of the club this year was to win the CAF Champions League a fifth time."
"I am so happy in Lubumbashi because we are treated like royalty," explained Ghanaian midfielder Daniel Nii Adjei, who came off the bench in Algiers.
"The atmosphere is conducive for training and playing. Footballers are treated like professionals."
After winning impressively in Algiers, the 'Ravens' are expected to conquer Africa for the first time since 2010, when they crushed Esperance of Tunisia 6-1 overall. Mazembe also won the premier African club football competition the previous year, and are the only sub-Saharan side to achieve the feat since 2004.
North African teams have dominated the CAF Champions League with eight of the last 10 title-holders coming from Egypt or Tunisia. But expensively-assembled Mazembe have proven formidable rivals, reaching the semi-finals twice since lasting holding the trophy.
No one at Mazembe craves success more than French coach Patrice Carteron, after a couple of CAF near-misses. After resigning as Mali coach, he had to settle for a runners-up medal in the second-tier CAF Confederation Cup when CS Sfaxien won the 2013 final through a last-minute goal in DR Congo.
Last year, Mazembe were expected to overcome Entente Setif of Algeria in the Champions League semi-finals, but a couple of clangers by veteran goalkeeper Muteba Kidiaba cost them dearly.
"USM are dangerous because they have nothing to lose," warned 45-year-old former Lyon and Saint-Etienne defender Carteron.
"Winning in Algeria was a magnificent achievement. The team were well prepared mentally and showed determination and character.
"We must use our attacking strength to achieve another victory. It is the only way we know how to play."
Mazembe have been outstanding at home in recent CAF games, overwhelming Moghreb Tetouan of Morocco 5-0 to make the semi-finals, then outclassing Al Merrikh of Sudan 3-0 to reach the final. Four of the eight goals in those games came from Tanzanian Mbwana Samatta, who needs two more to overtake leading 2015 CAF Champions League scorer Bakry 'Al Medina' Babiker of Merrikh.
First-time CAF finalists USM can draw some hope from a 2-1 away win over Al Hilal of Sudan in the semi-finals -- a similar result in Lubumbashi would take the final to a penalty shootout.But goalkeeper Mohamed Zemmamouche, whose outstanding saves prevented a heavier first-leg loss, accepts that "our mission is very complicated.
"We will try to redeem ourselves in Lubumbashi. My team have only lost a battle, not the war. Mazembe are a great club with more experienced players than us," he said.
"There is a second chance for us and we have to play with all our strength to make amends."
Midfielders Rainford Kalaba of Mazembe and Hocine El Orfi of USM, both red-carded in the first leg, miss the return match, as does suspended USM captain and defender Nacereddine Khoualed.