Both teams won at unfamiliar grounds and put themselves in good stead for the final hurdle, where two teams will emerge to represent the continent at the global championship.
By nine minutes, the West Africans were up by two goals through Chinaza Uchendu, who scored after six minutes before Veronica Chinwendu added the second three minutes later. The Congolese, two-time participants at the world championships, 2006 (Russia) and 2008 (Chile) pulled one back through Hornella Lengi Salu.
In Malabo, Equatorial Guinea were handed a lone goal defeat by the visiting Ghanaian Princesses. Wasila Diwura-Soale scored the only goal nine minutes before the break.
In Lusaka, Zambia were held to a barren draw by South Africa in a regional derby on Sunday.
Meanwhile, the encounter between Burkina Faso and Ethiopia has been rescheduled for Sunday, 3 October 2015 at the Municipal Stadium in Ouagadougou.
The second leg matches are set for the weekend of 9-11 October 2015 with the winners progressing to the final round.
Sunday, 27 September 2015
Equatorial Guinea 0-1 Ghana
DR Congo 1-2 Nigeria
Zambia 0-0 South Africa
*Burkina Faso vs Ethiopia
*rescheduled for 3 October 2015 at the Municipal Stadium, Ouagadougou