In doing so, the USA won their fourth world crown in the last five outings of the event.
They showcased their outstanding depth and talent from the outset, with Maya Moore scoring eight quick-fire points to carve out a double-digit lead at 15-5.
The Spaniards trailed 48-29 at halftime but fought back in the third quarter when Alba Torrens came to life with 10 points in the period.
The USA continued to engage cruise control as their depth in scoring and some terrific defense allowed them to head into the final quarter up 67-48.
Spain produced a late rally, holding their opponents to just 10 points over the closing 10 minutes to reduce the final margin and finish on a high note. Click here for the full game report.
Moore, who had 18 points, 4 rebounds, 2 assists and a steal in the Final, was rewarded for her impressive play in the tournament by receiving the Most Valuable Player awarded, presented by Tissot.
The 25-year-old headlined the All-Star Five which also included the Spanish pair of Alba Torrens and Sancho Lyttle, Australia's Penny Taylor and Moore's USA team-mate Brittney Griner.
Australia claimed third place after stunning Turkey with a spectacular start to secure a stunning 74-44 success against the local favourites. Click here for the full game report.
In the 5-8 Classification Games, Canada claimed fifth place with a 61-53 win over China, while France finished seventh after beating Serbia 88-74.
Final Standings of 2014 FIBA World Championship for Women:
9. Czech Republic