Zainah Angellah Lokwameri and Sarah Ageno added 17 and 16 points in that order to make their intentions at the tournament known.
"It was very important for us to win our first game to give us momentum in the tournament. Every game is a final here because we are playing a round-robin," Sarah Ageno said.
UCU, who finished fourth at last year's edition, are looking to finish among the top two sides for a place at the FIBA Africa Champions Cup Women 2017 that will be held in November in Luanda, Angola.
In an interview with FIBA.basketball after the game, Ageno said, "It was very important for us to win our first game to give us momentum in the tournament. Every game is a final here because we are playing a round-robin."
Meanwhile, Kenyan champions Equity Hawks defeated Tanzania's Don Bosco 68-48 in a one-sided encounter that saw the bankers make a perfect debut at the regional competition.
Hawks captain Hilda Indasi Luvandwa scored a game high 20 points and made five assists while Kenyan league MVP Mercy Wanyama added 14 points and picked an incredible 16 rebounds, 15 of them defensive.
"This being a round-robin tournament, we have to take one game at a time. Every team is here for the trophy and I am happy that we won our game," the contented Luvandwa said.
Center Martha Soigi sunk 23 points and picked seven rebounds as KCCA Leopards saw off a stubborn APR side 57-45. Shooting guard Joy Chemutai added 17 points for the tournament regulars.