round-of-32 second-leg triumph in the Zambezi derby.
Davy Daka completed the scoring with three minutes left as Zanaco secured a final qualifying round date with Stade Gabesien of Tunisia.
There were goals galore in Dar es Salaam as Azam of Tanzania beat Wits of South Africa 4-3 to complete a double over the Johannesburg outfit having won
Dismissed as "no hopers" by coach Gavin Hunt before the return match, Wits gave a much better performance in East Africa than at home.
Ivorian Kipre Tchetche claimed the first hat-trick of the Confederation Cup this season and captain John Bocco was the other scorer for the Tanzanian ice cream company club.
Abednago Mosiatlhaga, Jabulani Shongwe and veteran former Namibia star Henrico Botes scored for Wits, who three times during the match fell two goals behind.
First-half goals in quick succession from Emmanuel Yeboah and Abass Mohammed delivered a 2-0 win for Medeama of Ghana over Al Ittihad of Libya in Sekondi and a last-16 place.
The Libyans, unable to play competitive football at home because of post-Moamer Kadhafi era lawlessness, led 1-0 from the first meeting in Tunisian city Sfax.
Al Ahly Shendy are the next opponents for Medeama, as the Sudanese side squeezed past Saint Eloi Lupopo of the Democratic Republic of Congo on away goals after a 2-2 aggregate draw.
The lone second-leg goal in Shendy, 150 kilometres north of Khartoum, came after eight minutes from Nigeria-born Kelechi Osunwa.
Kawkab Marrakech of Morocco got a fright for the second successive round before setting up a North African derby with Mouloudia Oran of Algeria.
Three goals up against Barrack Young Controllers II of Liberia after the first leg, Kawkab conceded two late goals to lose 2-0 in Monrovia.
Marrakech surrendered a three-goal preliminary-round, first-leg lead to Burkina Faso armed forces side USFA before winning on penalties.
ENPPI of Egypt and Mounana of Gabon set up a last-16 meeting after three-goal home victories over Africa Sports of Ivory Coast and Atletico Olympic of Burundi respectively.