The summer arrival from Metz was forced to sit out the 2-2 draw at Stoke City at the weekend after suffering the knock in the recent victory over reigning champions Manchester City.
Sakho scored the crucial second goal as West Ham won 2-1 at home to City on 25 October, as the 24-year-old made it six goals in his first six Premier League starts - and seven in seven in all competitions. A collision with City goalkeeper Joe Hart led to Sakho being substituted, and he was not risked at the Britannia Stadium as Sam Allardyce's side came from two goals down to take a point.
But Stijn Vandenbrouke, West Ham's head of medical and sports science, has revealed Sakho will be back at Upton Park on Saturday - and also confirmed club-record signing Andy Carroll is closing in on a first-team return having been ruled out since a pre-season ankle operation.
Allardyce will be further boosted by the news Winston Reid will also be available to take on out-of-form Villa after the New Zealand international suffered a dead leg at Stoke.
The point against Mark Hughes's side leaves West Ham fifth in the table, level with Arsenal having won half of their opening ten fixtures.