Lomachenko will defend his WBA, WBO belts and his WBC franchise title against IBF champion Teofimo Lopez.
The bout on 17 October is the biggest since the Covid-19 pandemic began.
Asked why hold it now without fans, Lomachenko told BBC Sport: "Because nobody knows when this finishes."
The 32-year-old Ukrainian added: "Because it is close to my goal, my dream. That's why I want to take this."
Lopez (right) is undefeated in 15 bouts and won the IBF lightweight title in December