The Black Stars will face the Cranes of Uganda on Saturday, 15 November 2014 in Kampala before returning to the northern Ghanaian city of Tamale four days later for the ultimate Group E fixture against neighbours, Hawks of Togo.
Gyan, who plays for United Arab Emirates outfit, Al Ain, is ruled out of the two games due to injury just as the Italian-based Asamoah.
In the place of Gyan, who is Ghana’s top scorer in the campaign with three goals, coach Maxwell Konadu has called up Emmanuel Osei Banahene of Saudi Arabian side, Al Orobah.
Ghana has eight points, Togo with six points, with Uganda and Guinea in that order with four points apiece.
Goalkeepers: Fatau Dauda (AshGold), Adams Stephen (Aduana Stars) and Razak Braimah (Mirandes FC, Spain)
Defenders: Yaw Frimpong (TP Mazembe, DR Congo), Harrison Afful (Esperance FC, Tunisia), Awal Mohammed (Maritzburg, South Africa), Baba Rahman (FC Augsburg, Germany), Jeffery Schlupp (Leicester City, England), John Boye (Erciyesspor, Turkey), Kwabena Adusei (Mpumalanga Black Aces, South Africa), Jonathan Mensah (Evian, France)
Midfielders: Emmanuel Agyemang-Badu (Udinese, Italy), Rabiu Mohammed (Krasnodar, Russia), Mubarak Wakaso (Celtic, Scotland), Atsu Christian (Everton, England), Asante Solomon (T.P. Mazembe, DR Congo), Gyimah Edwin (Mpumalanga Black Aces, South Africa), Afriyie Acquah (Parma FC, Italy) Andre Ayew (Olympique Marseille, France)
Forwards: Jordan Ayew (Lorient, France), Abdul-Majeed Waris (Trabzonspor, Turkey), David Accam (Helsenborg, Sweden), Emmanuel Osei Banahene, (Al Orobah, Saudi Arabia)