Tournament debutant Uganda led for the opening 35 seconds of the game but very soon Chamberlain Oguchi made sure to end their expectations.
The Nigerian shooting guard responded with electrifying plays to set a tournament high, by hitting 8 of his 14 three-point attempts.
It was Uganda's second defeat in as many games in the event. They face the Central African Republic (CAF) on Sunday.
Meanwhile, Stan Okoye made headlines not so much for his 10 points in Nigeria's winning effort, but for breaking the backboard after attacking the basket with such ferocity with 2:17 left to play. The game resumed after an hour-long period to replace the backboard.
Turning Point: With the exception of the first 35 seconds, Nigeria led for the entire the contest.
Stats Don't Lie: Uganda made only 48 percent of their free-throw attempts. They hit 31 percent of their field-goals.
Game Hero: After inspiring Nigeria in their tournament opening win over CAF, Oguchi continued to assume a leadership role.
The Bottom Line: It was total dominance from the Nigerians, who will face hosts Tunisia on Sunday in the highly-anticipated game of group A. The Ugandans, however, showed a combative attitude, but needed a little bit more than that. They needed to be more efficient at both ends of the floor.