Lidoda Duvha produced the upset of the tournament so far on Saturday after dispatching Kaizer Chiefs 2-1 at the FNB Stadium, with Morgan Shivambu and Roggert Nyundu getting the goals for the second-tier club to shock the Premiership leaders.
Meanwhile, SuperSport United issued a big signal of their intent after dumping out defending champions Orlando Pirates, and Matsatsantsa will now continue their title quest against Golden Arrows.
Mamelodi Sundowns coasted into the last-eight after a determined second-half display at the weekend saw them dispatch Platinum Stars 3-1, and they will now take on Premiership rivals Mpumalanga Black Aces.
Full Nedbank Cup quarter-final draw:
Black Leopards v Vasco da Gama
SuperSport United v Golden Arrows
Ajax Cape Town v Bidvest Wits
Mpumalanga Black Aces v Mamelodi Sundowns