Malepe will be serving his one match suspension following the second yellow card he received in the qualifiers against Lesotho in June last year.
Head Coach Thabo Senong believes that although the captain will be missed, they have prepared for this.
“We have obviously had to make some changes in defence – we have shifted players to fill up his position, but we are confident that our strategy will work against Cameroon, who we know are no pushovers.”
The Burger King-sponsored Amajita will be led by vice captain Teboho Mokoena. Goalkeeper Mondli Mpoto is the second vice captain.
The Group B clash between Amajita and the Indomitable Lions of Cameroon will kickoff at 18h00. Earlier, Senegal will face off with Sudan at 15h00.
The matches will be broadcast live on SuperSport 9.