The 26-year old, has been ruled out of action for at least four months after limping off on his debut for new club, West Ham last week. His absence is not expected to serve a big blow as the Black Stars have already booked their ticket to Gabon and sit atop Group H standings on 13 points, seven more than second place Rwanda.
Ghana, unbeaten in their previous five matches beat Rwanda 1-0 in the reverse in Kigali last September. Mozambique will play host to Mauritius in the other Group H clash in Maputo.
Goalkeepers: Razak Braimah (Cordoba, Spain), Adam Kwarasey (Rosenborg, Norway) Richard Ofori (Wa All Stars)
Defenders: Harrison Afful (Columbus Crew, USA), Daniel Amartey (Leicester City, England), Jeffery Schlupp (Leicester City, England), Baba Rahman (Schalke, Germany), John Boye (Sivasspor, Turkey), Jonathan Mensah (Anzhi, Russia), Edwin Gyimah (Orlando Pirates, South Africa), Kadri Mohammed (AshantiGold)
Midfielders: Emmanuel Agyemang-Badu (Udinese, Italy), Afriyie Acquah (Torino, Italy), Thomas Partey (Atletico Madrid, Spain) Samuel Tetteh (Leifering, Austria), Mubarak Wakaso (Panathinaikos, Greece), Frank Acheampong (Anderlecht, Belgium), Alfred Duncan (Sassuolo, Italy), Christian Atsu (Chelsea, England)
Forwards: Asamoah Gyan (Shanghai SIPG, China), Jordan Ayew (Aston Villa, England), Ebenezer Assifuah (Sion, Switzerland), David Accam (Chicago Fire, USA).