Ghana put up an impressive performance in the first half when striker Jane Ayiyiam cancelled out Nadeshiko's 14th minute goal.
In the second half, the Queens capitulated and conceded five more goals.
Last year, Ghana were hammered 8-0 by France in friendly played in Reims.
The friendly formed part of Ghana's preparations towards hosting this years African Women's Cup of Nations in Ghana.
The Queens recently won the WAFU Nations Cup and will use this exercise to improve ahead of the tournament in November.
From Sammy Heywood Okine