Cuper, 59, replaces Egyptian Shawky Gharib, who was sacked following the Pharaoh’s inability to qualify for the 2015 Orange Africa Cup of Nations in Equatorial Guinea.
A statement on the EFA website said: The Board of Management of the Egyptian Football Association officially announced at a meeting today (Monday, 2 March 2015) under the chairmanship of Mr. Gamal Alam the appointment of Argentine Hector Cuper as coach of the national first team.
His main target is to qualify the seven-time African champions to the 2018 FIFA World Cup in Russia whilst details of his contract remain sketchy.
The Egypt job is the first in Africa for Cuper, whose only stint in charge of a national side was with Georgia between 2008 and 2009.
His last job was with United Arab Emirates outfit, Al Wasl before his stay ended in March 2014 due to poor results.
The Argentine earned global fame after guiding Spanish side, Valencia to successive finals of the UEFA Champions League losing on both occasions to Real Madrid and Bayern Munich in 2000 and 2001 respectively.
He has also had stints Spanish sides, Real Mallorca, Real Betis and Racing Santander, Orduspor of Turkey as well as Italian duo, Inter Milan and Parma.