
The 38-year-old, who captained Senegal to the quarter-finals of the 2002 FIFA World Cup™, succeeds Alain Giresse after the Frenchman departed following the Lions of Teranga's first-round exit from this year's Africa Cup of Nations.
A tweet from the Senegalese federation's official account confirmed Cisse's appointment.
Reports suggest the former Paris Saint-Germain player has signed a four-year contract after stepping up from an assistant's role.