The visitors had a bright start by showing urgency and intensity inside the opening minutes of the game.
Uganda quickly recovered and a well-orchestrated move two minutes later yielded a corner but could not yield anything as Miya Farouk side netted.
Ssekisambu shot wide after on the quarter-hour mark before lanky goalkeeper Stephane Bitseki Moto came to the visitors rescue.
In the 33rd minute, right back Dennis Okot met a Miya pass and Ssekisambu was perfectly stationed to nod home the opener past CF Mounana's goalkeeper Moto.
Ntsitsigui Ewouta of AS Mangasport replied for the visitors with barely 10 minutes left on the clock.
In the second half Cranes tactician Milutin Sredejovic Micho called for four changes as the second half of the game started.
Muzamir Mutyaba and Francis Olaki were the first two changes and they replaced captain Miya and Ceasar Okhuti respectively. Ivan Ntege also came in for Ssekisambu, Mathias Kigonya replaced Ismail Watenga and Robert Sentongo paved way for Frank Kalanda.
Gabon made three changes too; Georges Anaboubrouet replaced Cyrive Avebe Engozo’o, Lionel Richie Yackou came on for Kabi Tche Djesnot as Wils Vladimir came also Knox Ness Younga.
Uganda will play Cameroon as their next test game before they fly to Kigali for the CHAN where they are housed in Rubavu-based Group D with Mali, Zambia and Zimbabwe.
Uganda Cranes XI: Ismail Watenga (G.K), Dennis Okot, Joseph Ochaya, Benard Muwanga, Richard Kasagga Juuko, Timothy Dennis Awany Kezironi Kizito, Erisa Ssekisambu, Faruku Miya, Ceasar Okhuti, Robert Sentongo
Subs: Mathias Kigonya, Ivan Ntege, Isaac Muleme, Hassan Wasswa Dazzo, Frank Kalanda, Francis Olaki, Muzamir Mutyaba, Ambrose Kirya
Gabon XI: Stephane Moto Bitseki (G.K), Rodrigue Moundounga, Stevy Gucvane Nzambe, Prince Junior Ndinga Ongolo, Franck Obambou, Cyrive Avebe Engozo’o, Kabi Tche Djesnot, Knox Ness Younga, Cedric Ondo Biyoghe, Allen Dorian, Abdou Atchabao
Subs: Laurhian Kanstouga (G.K), Paulin Roger Nzanbi (G.K), Essono Heyong Stephane, Aaaron Salem Boupenda, Yann Jose Gnassa Nangonda, Georges Anaboubrouet, Lionel Richie Yackou, Wils Vladimir Ogoula Aworet, Ronald Ntsitsigui