Despite the best efforts of Augusto Matos, Mozambique never posed a real threat as the Western Africans led for all of 20 seconds.
Matos, the only player to score in double digits for his team, finished with a joint game-high 14 points, but that wasn't enough to avoid elimination for the Mozambicans.
Nigeria will take on Gabon in the Quarter-Finals on Thursday.
Turning Point: Nigeria dominated the contest throughout, and although Mozambique used a 6-0 run in the third quarter to show signs of life, the Nigerians clearly had more options to close out the game.
Stats Don't Lie: As a result of Mozambique's small line-up, Nigeria came up with a 55-29 rebounding advantage. But Mozambique's tendency to favour one-on-one plays also damaged their aspirations as they turned the ball over 20 times.
Game Hero: Matos accounted for three of Mozambique's four three-pointers, made all his three free-throws, but it wasn't meant to be Mozambique's turn to reach the Quarter-Finals for the first time since 1995.
The Bottom Line: Mozambique's small line-up proved costly once again, as they never posed threat in the paint. Nigeria's athleticism made a significant difference in the outcome of the game.